INFRAACT combines complementary scientific platforms so that projects can move from an initial biological question to integrated experimental evidence. Access is shaped around the project’s purpose, the required level of validation and the next translational decision.
ONE CONNECTED TRANSLATIONAL WORKFLOW
From a scientific question to the next step
1 · Define the question
Clarify the biological problem, intended application and evidence required for the next decision.
2 · Connect expertise
Identify the relevant models, technologies, specialists and institutional partners.
3 · Generate integrated evidence
Combine robust experimentation, biological characterisation and reproducible data analysis.
4 · Plan the next step
Use the resulting evidence to guide further validation, partnership or biomedical application.
Advanced cell models
Cell-based systems provide the biological foundation for mechanistic studies, disease modelling, target exploration and preclinical research. INFRAACT partners contribute complementary experience with human and animal cell systems and experimentally relevant culture formats.
- Primary and established cell cultures
- Stem-cell and induced pluripotent stem-cell approaches
- Two-dimensional and three-dimensional culture models
- Organoid, spheroid and co-culture strategies where appropriate
- Functional cellular assays tailored to the research question
Multi-omics and molecular profiling
Molecular profiling can reveal the pathways, signatures and candidate biomarkers associated with a biological state or intervention. INFRAACT helps projects identify an appropriate analytical strategy and connect complementary datasets.
- Genomic and transcriptomic approaches
- Proteomic and related molecular analyses
- Biomarker-oriented study design
- Integration of complementary molecular datasets
- Interpretation in relation to cellular phenotype and project purpose
Imaging and phenotyping
Imaging and quantitative phenotyping connect molecular findings with cellular organisation, morphology and function. The analytical approach is selected according to the model, endpoint and degree of validation required.
- Microscopy-based cellular characterisation
- Quantitative image analysis
- Phenotypic and functional readouts
- Comparative evaluation across experimental conditions
- Integration with molecular and multi-omics findings
Bioinformatics and data expertise
Reproducible data handling and interpretation are essential parts of an integrated experimental workflow. INFRAACT connects projects with expertise suited to the data type, scientific question and collaboration context.
- Data processing and quality assessment
- Statistical and computational analysis
- Integration of heterogeneous datasets
- Reproducible and collaborative workflows
- Support for FAIR-oriented research practices
Capabilities are combined around the project
Not every project requires every platform. The relevant combination of models, analytical technologies and data expertise is defined during an initial scientific discussion. Availability, feasibility, timelines and the roles of participating partners are then confirmed for the proposed work.
Where appropriate, EATRIS Bulgaria can also connect national capabilities with European expertise, services, training and partnership opportunities.
